Anti-CD11b（APC）Monoclonal Antibody - SAlexa Fluor 488
Cat: K009928M - SAlexa Fluor 488
Summary:
| 【Product name】：Anti-CD11b（APC）Monoclonal Antibody - SAlexa Fluor 488 | 【Source】：Rat |
| 【Isotype】：IgG2b，κ | 【Purification】：Affinity purification |
| 【Gene ID】：16409 | 【Swiss Prot】：E9Q604 |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes | |
| 【Storage】：Store at 2-8℃. Avoid exposure to light. | |
Background:
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).
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