Anti-TASL Polyclonal Antibody - SAlexa Fluor 750
Cat: K111372P - SAlexa Fluor 750
Summary:
| 【Product name】：Anti-TASL Polyclonal Antibody - SAlexa Fluor 750 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：80231 | 【Swiss Prot】：Q9HAI6 |
| 【Tested applications】：IHC,ELISA,WB | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:100-300. | |
| 【Immunogen】：Recombinant protein of human TASL | |
| 【Public Immunogen Range】：1-302aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons (PubMed:32433612). Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes (PubMed:31001245).
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