Anti-TNFRSF11B Polyclonal Antibody - SAlexa Fluor 640
Cat: K111421P - SAlexa Fluor 640
Summary:
| 【Product name】：Anti-TNFRSF11B Polyclonal Antibody - SAlexa Fluor 640 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：4982 | 【Swiss Prot】：O00300 |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:2000-5000.;IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human TNFRSF11B | |
| 【Public Immunogen Range】：20-370aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
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