Anti-LIG4 Polyclonal Antibody
Cat: K111521P
Summary:
| 【Product name】：Anti-LIG4 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：3981 | 【Swiss Prot】：P49917 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human LIG4 | |
| 【Public Immunogen Range】：425-475/911aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Verified picture:
Immunohistochemistry of paraffin-embedded Human breast cancer with LIG4 antibody diluted at 1:80.
Immunohistochemistry of paraffin-embedded Human pancreatic cancer with LIG4 antibody diluted at 1:80.