Anti-XRN2 Polyclonal Antibody
Cat: K111537P
Summary:
| 【Product name】：Anti-XRN2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：22803 | 【Swiss Prot】：Q9H0D6 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:100-300. | |
| 【Immunogen】：A synthetic peptide of human XRN2 | |
| 【Public Immunogen Range】：500-550/950aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites.
Verified picture:
Immunohistochemistry of paraffin-embedded Human pancreatic cancer with XRN2 antibody diluted at 1:200.
Immunohistochemistry of paraffin-embedded Human stomach cancer with XRN2 antibody diluted at 1:200.
Immunohistochemistry of paraffin-embedded Human thyroid cancer with XRN2 antibody diluted at 1:200.