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Anti-CSE1L Polyclonal Antibody - SAlexa Fluor 640
Cat: K111546P - SAlexa Fluor 640
Summary:
【Product name】:Anti-CSE1L Polyclonal Antibody - SAlexa Fluor 640 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:1434 【Swiss Prot】:P55060
【Tested applications】:IHC
【Recommended dilution】:IHC 1:50-200.
【Immunogen】:A synthetic peptide of human CSE1L
【Public Immunogen Range】:265-315/971aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Verified picture: