Anti-NPL Polyclonal Antibody
Cat: K111649P
Summary:
| 【Product name】：Anti-NPL Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：80896 | 【Swiss Prot】：Q9BXD5 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:1000-3000;IHC 1:100-300. | |
| 【Immunogen】：Recombinant protein of human NPL | |
| 【Public Immunogen Range】：1-241aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity).
Verified picture:
Western blot analysis with NPL antibody diluted at 1:2000;Lane: THP-1.
Immunohistochemistry of paraffin-embedded Human esophageal cancer with NPL antibody diluted at 1:200.