Anti-INS Polyclonal Antibody
Cat: K111620P
Summary:
| 【Product name】：Anti-INS Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：3630 | 【Swiss Prot】：P01308 |
| 【Tested applications】：IHC;IF,IHC,IF | |
| 【Recommended dilution】：IHC 1:50-200. IF 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human INS | |
| 【Public Immunogen Range】：15-65/110aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with INS antibody diluted at 1:100