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Anti-BABAM2 Polyclonal Antibody
Cat: K111971P
Summary:
【Product name】:Anti-BABAM2 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Octanoic acid-ammonium sulfate precipitation
【Gene ID】:9577 【Swiss Prot】:Q9NXR7
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:1000-3000.;IHC 1:50-200.
【Immunogen】:Recombinant protein of human BABAM2
【Public Immunogen Range】:1-383aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748).In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748).Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665).Within the BRISC complex, acts as an adapter that bridges the interaction between BABA
Verified picture:
Western blot analysis with BABAM2 antibody diluted at 1:2000.Lane: HT29.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with BABAM2 antibody diluted at 1:100.