Anti-SSBP1 Polyclonal Antibody - SAlexa Fluor 640
Cat: K112001P - SAlexa Fluor 640
Summary:
| 【Product name】：Anti-SSBP1 Polyclonal Antibody - SAlexa Fluor 640 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：6742 | 【Swiss Prot】：Q04837 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:1000-3000.; IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human SSBP1 | |
| 【Public Immunogen Range】：1-148aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair.
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