Anti-RAPGEF3 Polyclonal Antibody
Cat: K112028P
Summary:
| 【Product name】：Anti-RAPGEF3 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：10411 | 【Swiss Prot】：O95398 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:100-300. | |
| 【Immunogen】：Recombinant protein of human RAPGEF3 | |
| 【Public Immunogen Range】：1-332aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Verified picture:
Immunohistochemistry of paraffin-embedded Human Colorectal cancer with RAPGEF3 antibody diluted at 1:200.