Anti-ERLIN2 Polyclonal Antibody
Cat: K112035P
Summary:
| 【Product name】：Anti-ERLIN2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：11160 | 【Swiss Prot】：O94905 |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000.; IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human ERLIN2 | |
| 【Public Immunogen Range】：1-153aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex.
Verified picture:
Western blot analysis with ERLIN2 antibody diluted at 1:2000;Lane: 293T.
Immunohistochemistry of paraffin-embedded Human Breast cancer with ERLIN2 antibody diluted at 1:100.