Anti-FBXO38 Polyclonal Antibody
Cat: K112047P
Summary:
| 【Product name】：Anti-FBXO38 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：81545 | 【Swiss Prot】：Q6PIJ6 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human FBXO38 | |
| 【Public Immunogen Range】：763-1114aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity.Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival.May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination.
Verified picture:
Immunohistochemistry of paraffin-embedded Human Breast cancer with FBXO38 antibody diluted at 1:100.