Anti-CENATAC Polyclonal Antibody
Cat: K112049P
Summary:
| 【Product name】：Anti-CENATAC Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：338657 | 【Swiss Prot】：Q86UT8 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human CENATAC | |
| 【Public Immunogen Range】：1-332aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Negative regulator of centrosome duplication .Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1.
Verified picture:
Immunohistochemistry of paraffin-embedded Human Colorectal cancer with CENATAC antibody diluted at 1:100.