Anti-NLRP1 Polyclonal Antibody
Cat: K112078P
Summary:
| 【Product name】：Anti-NLRP1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：22861 | 【Swiss Prot】：Q9C000 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:25-100. | |
| 【Immunogen】：Recombinant protein of human NLRP1 | |
| 【Public Immunogen Range】：1-147aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
Verified picture:
Immunohistochemistry of paraffin-embedded human pancreatic cancer with NLRP1 antibody diluted at 1:50.