Anti-DEPDC5 Polyclonal Antibody
Cat: K112079P
Summary:
| 【Product name】：Anti-DEPDC5 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：9681 | 【Swiss Prot】：O75140 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human DEPDC5 | |
| 【Public Immunogen Range】：211-560 | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Verified picture:
Immunohistochemistry of paraffin-embedded human colorectal cancer with DEPDC5 antibody diluted at 1:100.