Anti-ABCA8 Polyclonal Antibody
Cat: K112092P
Summary:
| 【Product name】：Anti-ABCA8 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：10351 | 【Swiss Prot】：O94911 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human ABCA8 | |
| 【Public Immunogen Range】：60-215aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Catalyzes the import of organic anions such as taurocholate and estrone sulfate in an ATP-dependent manner (PubMed:12379217).In vitro, also imports ochratoxin A (PubMed:12379217).In addition mediates the cholesterol efflux in an apolipoprotein independent manner an plays a role in sphingomyelin production in oligodendrocytes (PubMed:23560799).Catalyzes the cholesterol and taurocholate efflux in an ATP-dependent manner (PubMed:29300488).Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels (PubMed:28882873).
Verified picture:
Immunohistochemistry of paraffin-embedded human liver cancer with ABCA8 antibody diluted at 1:100.