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Anti-DXO Polyclonal Antibody
Cat: K112111P
Summary:
【Product name】:Anti-DXO Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Octanoic acid-ammonium sulfate precipitation
【Gene ID】:1797 【Swiss Prot】:O77932
【Tested applications】:IHC
【Recommended dilution】:IHC 1:50-200.
【Immunogen】:Recombinant protein of human DXO
【Public Immunogen Range】:1-213aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.The NAD-cap is present at the 5'-end of some RNAs and snoRNAs (PubMed:28283058).In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:28283058).Preferentially acts on NAD-capped transcripts in response to environmental stress (PubMed:31101919).Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (By similarity).Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control (By similarity).Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (PubMed:29601584).In contrast to
Verified picture:
Immunohistochemistry of paraffin-embedded human breast cancer with DXO antibody diluted at 1:100.