Anti-RNF166 Polyclonal Antibody - SAlexa Fluor 405
Cat: K112130P - SAlexa Fluor 405
Summary:
| 【Product name】：Anti-RNF166 Polyclonal Antibody - SAlexa Fluor 405 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：115992 | 【Swiss Prot】：Q96A37 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human RNF166 | |
| 【Public Immunogen Range】：1-238aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896).In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896).Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228).Plays also a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896).Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896).
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