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Anti-CEP152 Polyclonal Antibody - SAlexa Fluor 660
Cat: K112158P - SAlexa Fluor 660
Summary:
【Product name】:Anti-CEP152 Polyclonal Antibody - SAlexa Fluor 660 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:22995 【Swiss Prot】:O94986
【Observed】:140kDa
【Tested applications】:WB,IHC
【Recommended dilution】:WB 1:1000-3000. IHC 1:50-200.
【Immunogen】:A synthetic peptide of Human CEP152
【Public Immunogen Range】:1595-1645/1710aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles.
Verified picture: