Anti-PRAG1 Polyclonal Antibody
Cat: K112164P
Summary:
| 【Product name】：Anti-PRAG1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：157285 | 【Swiss Prot】：Q86YV5 |
| 【Observed】：100kDa | |
| 【Tested applications】：IF,WB,IHC,ELISA | |
| 【Recommended dilution】：WB 1:1000-3000. IF 1:50-200. IHC 1:50-200. ELISA 1:3000-30000. | |
| 【Immunogen】：A synthetic peptide of Human PRAG1 | |
| 【Public Immunogen Range】：240-290/1406aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity).
Verified picture:
Western blot analysis with PRAG1 antibody diluted at 1:2000;Lane: U-251MG,MG63.
Immunohistochemistry of paraffin-embedded human endometrial cancer with PRAG1 antibody diluted at 1:100.