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Anti-TBC1D23 Polyclonal Antibody - Biotin
Cat: K112323P - Biotin
Summary:
【Product name】:Anti-TBC1D23 Polyclonal Antibody - Biotin 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:55773 【Swiss Prot】:Q9NUY8
【Observed】:73kDa
【Tested applications】:WB ELISA IHC ICC
【Recommended dilution】:WB 1:50-200. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200. IF 1:50-200
【Immunogen】:Recombinant protein of human TBC1D23
【Public Immunogen Range】:1-321aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking.Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles.Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1.Plays a role in brain development, including in cortical neuron positioning (By similarity).May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity).May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity).
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