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Anti-TBC1D23 Polyclonal Antibody
Cat: K112324P
Summary:
【Product name】:Anti-TBC1D23 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Octanoic acid-ammonium sulfate precipitation
【Gene ID】:55773 【Swiss Prot】:Q9NUY8
【Tested applications】:IHC
【Recommended dilution】:IHC 1:50-200.
【Immunogen】:Recombinant protein of human TBC1D23
【Public Immunogen Range】:1-321aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking.Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles.Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1.Plays a role in brain development, including in cortical neuron positioning (By similarity).May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity).May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity).
Verified picture:
Immunohistochemistry of paraffin-embedded human endometrial cancer with TBC1D23 antibody diluted at 1:100