Anti-Cytokeratin 1-specific Polyclonal Antibody
Cat: K010034P
Summary:
| 【Product name】：Anti-Cytokeratin 1-specific Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：3848 | 【Swiss Prot】：P04264 |
| 【Observed】：67kDa | |
| 【Tested applications】：WB,ELISA,IF,IHC,IP | |
| 【Recommended dilution】：WB 1:500-2000. IHC 1:20-200. IF 1:20-200. | |
| 【Immunogen】：A synthetic peptide of human Cytokeratin 1 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9-K23, and the hair keratins Ha1-Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1-K8, and the hair keratins, Hb1-Hb6. Keratin-1 is type II keratin. It is a specific marker for terminal differentiation in mammalian epidermis. It is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. This antibody is specifically against ketatin I.
Verified picture:
Western blot analysis with Cytokeratin 1 antibody diluted at 1:1000;Lane: Rat skin Mouse skin.
Immunohistochemistry of paraffin-embedded human skin with Cytokeratin 1 antibody diluted at 1:100
Immunofluorescence analysis of A431 cells using Cytokeratin 1 antibody diluted at 1:50.