Summary:
copper metabolism (Murr1) domain containing 1
Cat：P06302
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-191aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： COMMD1 |
| 【Full Name】： copper metabolism (Murr1) domain containing 1 |
| 【Uniprot】： Q8N668 |
| 【Gene ID】： 150684 |
| 【Species Reactivity】： Human Mouse (Bovine Dog) |
| 【Mol Mass】： 21kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins.Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1;in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237).Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation.Down-regulates NF-kappa-B activity (PubMed:15799966，PubMed:17183367，PubMed:20048074).Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529).Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L.Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214，PubMed:20237237，PubMed:21741370).Promotes CFTR cell surface expression t
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