Summary:
protein phosphatase 1, regulatory (inhibitor) subunit 11
Cat：P06476
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-127aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： PPP1R11 |
| 【Full Name】： protein phosphatase 1，regulatory (inhibitor) subunit 11 |
| 【Uniprot】： O60927 |
| 【Gene ID】： 6992 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Zebrafish) |
| 【Mol Mass】： 14kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901).Inhibitor of protein phosphatase 1 (PubMed:9843442).
Verified picture
