Summary:
protein phosphatase 2C, magnesium-dependent, catalytic subunit
Cat：P06613
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 50-400aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： PPM2C |
| 【Full Name】： protein phosphatase 2C，magnesium-dependent，catalytic subunit |
| 【Uniprot】： Q9P0J1 |
| 【Gene ID】： 54704 |
| 【Mol Mass】： 39.5kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
PDP1 PDP，Pyruvate dehydrogenase (E1) is one of the three components (E1，E2，and E3) of the large pyruvate dehydrogenase complex.Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex.Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases.Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits.Two catalytic subunits have been reported;one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver.The catalytic subunit，encoded by this gene，is the former，and belongs to the protein phosphatase 2C (PP2C) superfamily.Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases，this enzyme is located in the mitochondrial matrix.Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency.Multiple alternat
Verified picture
