Summary:
poly(A)-specific ribonuclease (PARN)-like domain containing 1
Cat：P07132
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 100-450aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： PNLDC1 |
| 【Full Name】： poly(A)-specific ribonuclease (PARN)-like domain containing 1 |
| 【Uniprot】： Q8NA58 |
| 【Gene ID】： 154197 |
| 【Mol Mass】： 40.7kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
3'-exoribonuclease that has a preference for poly(A tails of mRNAs, thereby efficiently degrading poly(A tails. Exonucleolytic degradation of the poly(A tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. May act as a regulator of multipotency in embryonic stem cells (By similarity.
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