Summary:
cutaneous T-cell lymphoma-associated antigen 1
Cat：P07767
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 396-746aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CTAGE1 |
| 【Full Name】： cutaneous T-cell lymphoma-associated antigen 1 |
| 【Uniprot】： Q96RT6 |
| 【Gene ID】： 64693 |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Cutaneous T-cell lymphoma-associated antigen 1 (CTAGE1) is normally expressed only in testis tissue, and is found in 35% of CTCL tissues, but not in any leukemia or melanoma cell lines. The gene encoding for CTAGE1 maps to chromosome 18p11.2. CTAGE2 is a longer variant of CTAGE1 and is translated from a different open reading frame. Three other splice variants related to the major CTAGE1 and CTAGE2 variants exist, some of which are expressed only in testis, while others are expressed in a wide range of adult and fetal tissues. CTAGE1 may be an important factor in the specific immunotherapy of cutaneous T-cell lymphoma and other malignancies.
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