BCL7A Antibody Blocking Peptide

This gene is directly involved， with Myc and IgH， in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation， the N-terminal region of the gene product is disrupted， which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Jul 2008]