SPNS1 Antibody Blocking Peptide

Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949).Mediates the rate-limiting， proton-dependent， lysosomal efflux of lysophospholipids， which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949).Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE)， can also transport lysophosphatidylglycerol (LPG)， but not other anionic lysophospholipids， sphingosine， nor sphingomyelin (PubMed:36161949).Transports lysophospholipids with saturated， monounsaturated， and polyunsaturated fatty acids， such as 1-hexadecanoyl-sn-glycero-3-phosphocholine， 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z，7Z，10Z，13Z，16Z，19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine， respectively (PubMed:36161949).Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine (PubMe