ESR1 Antibody Blocking Peptide

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors， such as AP-1/c-Jun， c-Fos， ATF-2， Sp1 and Sp3， to mediate ERE-independent signaling.