CD14 Antibody Blocking Peptide

Coreceptor for bacterial lipopolysaccharide. In concert with LBP， binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex， thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88， TIRAP and TRAF6， leading to NF-kappa-B activation， cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides， these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway.