HGF Antibody Blocking Peptide

Hepatocyte growth factor regulates cell growth， cell motility， and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis， cell motility， and matrix invasion gives it a central role in angiogenesis， tumorogenesis， and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain.