TNFRSF10B Antibody Blocking Peptide

The protein encoded by this gene is a member of the TNF-receptor superfamily， and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L)， and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD， a death domain containing adaptor protein， is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.