GPR143 Antibody Blocking Peptide

Receptor for tyrosine， L-DOPA and dopamine. After binding to L-DOPA， stimulates Ca2+ influx into the cytoplasm， increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis， organization and transport.