NPAS4 Antibody Blocking Peptide

Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons， where it induces distinct but overlapping sets of late-response genes in these two types of neurons， allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit， thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons， activates transcription of BDNF， which in turn controls the number of GABA-releasing synapses that form on excitatory neurons， thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons， regu