ELAC2 Antibody Blocking Peptide

The protein encoded by this gene has a C-terminal domain with tRNA 3’ processing endoribonuclease activity， which catalyzes the removal of the 3’ trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1)， and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.