WDR41 Antibody Blocking Peptide

Non-catalytic component of the C9orf72-SMCR8 complex， a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190， PubMed:27103069， PubMed:27617292， PubMed:28195531).The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP， converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form， thereby promoting autophagosome maturation (PubMed:27103069).As part of the C9orf72-SMCR8 complex， stimulates RAB8A and RAB11A GTPase activity in vitro， however WDR42 is shown not be an essential complex component for this function (PubMed:32303654).The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069， PubMed:27617292).