Summary:
Recombinant human CDK9 protein
Cat：P02552
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-372aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CDK9 |
| 【Full Name】： cyclin-dependent kinase 9 |
| 【Uniprot】： P50750 |
| 【Gene ID】： 1025 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Zebrafish Chicken) |
| 【Mol Mass】： 43kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family.CDK family members are highly similar to the gene products of S.cerevisiae cdc28, and S.pombe cdc2, and known as important cell cycle regulators.This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II.This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K.HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
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