Summary:
Recombinant human C3 protein
Cat：P02621
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1314-1663aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： C3 |
| 【Full Name】： complement component 3 |
| 【Uniprot】： P01024 |
| 【Gene ID】： 718 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Pig) |
| 【Mol Mass】： 40kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Complement component C3 plays a central role in the activation of complement system.Its activation is required for both classical and alternative complement activation pathways.The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products.The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity.Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.
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