Summary:
Recombinant human CENPH protein
Cat：P02630
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-247aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CENPH |
| 【Full Name】： centromere protein H |
| 【Uniprot】： Q9H3R5 |
| 【Gene ID】： 64946 |
| 【Species Reactivity】： Human Mouse (Bovine Chicken) |
| 【Mol Mass】： 28kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation.The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase.It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase.It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C.Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.
Verified picture
