Summary:
Recombinant human CDC25B protein
Cat：P02654
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 240-580aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CDC25B |
| 【Full Name】： cell division cycle 25 homolog B |
| 【Uniprot】： P30305 |
| 【Gene ID】： 994 |
| 【Species Reactivity】： Human Mouse Rat |
| 【Mol Mass】： 37kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
CDC25B is a member of the CDC25 family of phosphatases.CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis.CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals.The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2.CDC25B has oncogenic properties, although its role in tumor formation has not been determined.Multiple transcript variants for this gene exist.
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