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Recombinant human HAX1 protein

Cat：P02656

Summary:

【Derived From】： E.coli

【Endotoxin】： Not measured

【Amino Acid】： 1-279aa

【Purity】： ≥85% by SDS-PAGE.

【Name】： HAX1

【Full Name】： HCLS1 associated protein X-1

【Uniprot】： O00165

【Gene ID】： 10456

【Species Reactivity】： Human Mouse Rat (Bovine)

【Mol Mass】： 32kDa

【Application】： Immunology research

【Purification】： NI-NTA affinity purification

【Bioactive】： N0

【Tag】： With a 6×His tag at the N/C-terminus.

【Concentration】： 1mg/ml by SDS-PAGE.

Store:

【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)

【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year.

【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0.

Background:

The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases.It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin.It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body.Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease.Two transcript variants encoding different isoforms have been found for this gene.

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