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Recombinant human PDK4 protein

Cat:P02690

Summary:

【Derived From】: E.coli
【Endotoxin】: Not measured
【Amino Acid】: 62-411aa
【Purity】: ≥85% by SDS-PAGE.
【Name】: PDK4
【Full Name】: pyruvate dehydrogenase kinase,isozyme 4
【Uniprot】: Q16654
【Gene ID】: 5166
【Species Reactivity】: Human Mouse Rat
【Mol Mass】: 40kDa
【Application】: Immunology research
【Purification】: NI-NTA affinity purification
【Bioactive】: N0
【Tag】: With a 6×His tag at the N/C-terminus.
【Concentration】: 1mg/ml by SDS-PAGE.

Store:

【Reconstitution】: Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
【Storage】: Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year.
【Formulation】: Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0.

Background:

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain.This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism.Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.

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