Summary:
Recombinant human TFPI protein
Cat：P02699
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-304aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： TFPI |
| 【Full Name】： tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| 【Uniprot】： P10646 |
| 【Gene ID】： 7035 |
| 【Species Reactivity】： Human Mouse Rat (Rabbit Bovine) |
| 【Mol Mass】： 35kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation.The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot.The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop.Inhibition of the encoded protein restores hemostasis in animal models of hemophilia.This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
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