Summary:
Recombinant human NR3C1 protein
Cat：P02715
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-300aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： NR3C1 |
| 【Full Name】： nuclear receptor subfamily 3，group C，member 1 |
| 【Uniprot】： P04150 |
| 【Gene ID】： 2908 |
| 【Species Reactivity】： Human Mouse Rat (Rabbit Pig Sheep Monkey Gorilla) |
| 【Mol Mass】： 33kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Receptor for glucocorticoids (GC) (PubMed:27120390).Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors.Affects inflammatory responses, cellular proliferation and differentiation in target tissues.Involved in chromatin remodeling (PubMed:9590696).Mutations in this gene are associated with generalized glucocorticoid resistance.Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms.Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
Verified picture
