Summary:
Recombinant human TNFA protein
Cat：P02740
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-233aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： TNFA |
| 【Full Name】： Tumor necrosis factor |
| 【Uniprot】： P01375 |
| 【Gene ID】： 7124 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Pig Horse Sheep Rabbit Monkey Dog) |
| 【Mol Mass】： 26kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily.This cytokine is mainly secreted by macrophages.It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.Knockout studies in mice also suggested the neuroprotective function of this cytokine.
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