Summary:
Recombinant human PLAU protein
Cat：P02755
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 82-431aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： PLAU |
| 【Full Name】： Urokinase-type plasminogen activator |
| 【Uniprot】： P00749 |
| 【Gene ID】： 5328 |
| 【Species Reactivity】： Human Mouse Rat (Rabbit Bovine Chicken Gorilla Pig) |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a secreted serine protease that converts plasminogen to plasmin.The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains.These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA).HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA).This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor.Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease.Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Verified picture
