Summary:
Recombinant human ZC3HC1 protein
Cat：P02782
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 291-502aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： ZC3HC1 |
| 【Full Name】： Nuclear-interacting partner of ALK |
| 【Uniprot】： Q86WB0 |
| 【Gene ID】： 51530 |
| 【Species Reactivity】： Human Mouse (Gorilla) |
| 【Mol Mass】： 23kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1).Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase.Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry.May have an antiapoptotic role in NPM-ALK-mediated signaling events.
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